Isy ochoa biography definition
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Abstract
Reprogramming somatic cells into iatrogenic pluripotent cover up cells (iPSCs) requires activating of say publicly pluripotency direction and resetting of say publicly epigenome wedge erasing say publicly epigenetic retention of say publicly somatic state of affairs. In human mouse cells, a depreciating epigenetic reprogramming step esteem the reactivation of representation inactive X chromosome. Teeth of its significance, a exhaustive understanding some the rigid networks linking pluripotency dominant X-reactivation pump up missing. Manuscript, we narrate important pathways for pluripotency acquisition abstruse X-reactivation magnificent a genome-wide CRISPR paravent during neuronic precursor end iPSC reprogramming. In isolated, we facts that activating of rendering interferon γ (IFNγ) trail early amid reprogramming accelerates pluripotency achievement and X-reactivation. IFNγ stimulates STAT3 sign and description pluripotency fabric and leads to enhanced TET-mediated Polymer demethylation, which consequently boosts X-reactivation. Awe therefore bring in a nonhuman understanding be alarmed about the parcel of IFNγ in reprogramming and X-reactivation and domestic animals a all right resource help the molecular networks implicated in these processes.
IFNγ direction during reprogramming enhances X-reactivation, which depends on TET-mediated DNA demethylation.
INTRODUCTION
A characteristic mark of embr
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Herman Braun-Vega
Peruvian painter and artist (1933–2019)
Herman Braun-Vega (7 July 1933 in Lima — 2 April 2019 in Paris)[1] was a Peruvian painter and artist.
Although his work has always been figurative, it was at first (before 1970) close to abstraction. It experienced a decisive turning point when the artist came to settle permanently in Paris in 1968. By being in contact with the works of the great masters of painting, Braun-Vega developed the art of pictorial quotation. He decided not to limit his painting to aesthetic research, but to adopt a clear pictorial language accessible to non-specialists even though his works often have several levels of reading. His painting, enriched with references to the history of art,[2] often depicts characters, landscapes, fruits and vegetables from his native Peru. He asserts his mixed origins through syncretic work, often very colorful, interspersed with political messages including transfers of press clippings. The artist, who had set himself as a policy not to paint for saying nothing, defines himself as a witness of his time who wants to activate the memory of the spectator. His artistic production is in line with the trends of New figuration (Nouvelle figuration)[3] and Narrative figuration
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Published in final edited form as: Cell Rep. 2024 May 2;43(5):114174. doi: 10.1016/j.celrep.2024.114174
Ryan Blawski
1Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21231, USA
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Bujamin H Vokshi
1Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21231, USA
14These authors contributed equally
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Xinyu Guo
2Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
14These authors contributed equally
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Srushti Kittane
3Department of Biochemistry and Molecular Biology, Johns Hopkins School of Public Health, Baltimore, MD 21205, USA
14These authors contributed equally
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Mirna Sallaku
4Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
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Wanlu Chen
2Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
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